Nature Communications (Aug 2018)
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways
- Indre Piragyte,
- Thomas Clapes,
- Aikaterini Polyzou,
- Ramon I. Klein Geltink,
- Stylianos Lefkopoulos,
- Na Yin,
- Pierre Cauchy,
- Jonathan D. Curtis,
- Lhéanna Klaeylé,
- Xavier Langa,
- Cora C. A. Beckmann,
- Marcin W. Wlodarski,
- Patrick Müller,
- Dominic Van Essen,
- Angelika Rambold,
- Friedrich G. Kapp,
- Marina Mione,
- Joerg M. Buescher,
- Erika L. Pearce,
- Alexander Polyzos,
- Eirini Trompouki
Affiliations
- Indre Piragyte
- Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics
- Thomas Clapes
- Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics
- Aikaterini Polyzou
- Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics
- Ramon I. Klein Geltink
- Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
- Stylianos Lefkopoulos
- Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics
- Na Yin
- Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics
- Pierre Cauchy
- Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics
- Jonathan D. Curtis
- Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
- Lhéanna Klaeylé
- Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics
- Xavier Langa
- Institute of Anatomy, University of Bern
- Cora C. A. Beckmann
- Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
- Marcin W. Wlodarski
- Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
- Patrick Müller
- Systems Biology of Development Group, Friedrich Miescher Laboratory of the Max Planck Society
- Dominic Van Essen
- Institute for Research on Cancer and Aging Nice
- Angelika Rambold
- Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics
- Friedrich G. Kapp
- Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
- Marina Mione
- Centre for Integrative Biology, University of Trento
- Joerg M. Buescher
- Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
- Erika L. Pearce
- Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics
- Alexander Polyzos
- Biomedical Research Foundation of the Academy of Athens
- Eirini Trompouki
- Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics
- DOI
- https://doi.org/10.1038/s41467-018-05311-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
HLX transcription factor regulates haematopoietic stem and progenitor cell (HSPC) differentiation and is overexpressed in acute myeloid leukemia. Here the authors show that HLX overexpression leads to myeloid differentiation block in zebrafish and human HSPCs by direct regulation of metabolic pathways.
