BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis

Abstract

BMP ligands act as retrograde signalling molecules to regulate presynaptic development, and regulation of BMP receptors by endocytosis may be an important component of this signalling pathway. Here, the authors show that Abi-mediated macropinocytosis of BMP receptors in Drosophila larva and contributes to neuromuscular development.