Nature Communications (Aug 2022)
A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes
- Allan L. Reiss,
- Booil Jo,
- Ana Maria Arbelaez,
- Eva Tsalikian,
- Bruce Buckingham,
- Stuart A. Weinzimer,
- Larry A. Fox,
- Allison Cato,
- Neil H. White,
- Michael Tansey,
- Tandy Aye,
- William Tamborlane,
- Kimberly Englert,
- John Lum,
- Paul Mazaika,
- Lara Foland-Ross,
- Matthew Marzelli,
- Nelly Mauras,
- the Diabetes Research in Children Network (DirecNet) Consortium
Affiliations
- Allan L. Reiss
- Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University
- Booil Jo
- Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University
- Ana Maria Arbelaez
- Divisions of Endocrinology & Diabetes, at Washington University in St, Louis
- Eva Tsalikian
- Stead Family Department of Pediatrics, Endocrinology and Diabetes, University of Iowa
- Bruce Buckingham
- Department of Pediatrics, Stanford University
- Stuart A. Weinzimer
- Department of Pediatrics, Yale University
- Larry A. Fox
- Division of Endocrinology, Diabetes & Metabolism, Nemours Children’s Health
- Allison Cato
- Division of Neurology, Nemours Children’s Health
- Neil H. White
- Divisions of Endocrinology & Diabetes, at Washington University in St, Louis
- Michael Tansey
- Stead Family Department of Pediatrics, Endocrinology and Diabetes, University of Iowa
- Tandy Aye
- Department of Pediatrics, Stanford University
- William Tamborlane
- Department of Pediatrics, Yale University
- Kimberly Englert
- Division of Endocrinology, Diabetes & Metabolism, Nemours Children’s Health
- John Lum
- Jaeb Center for Health Research
- Paul Mazaika
- Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University
- Lara Foland-Ross
- Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University
- Matthew Marzelli
- Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University
- Nelly Mauras
- Division of Endocrinology, Diabetes & Metabolism, Nemours Children’s Health
- the Diabetes Research in Children Network (DirecNet) Consortium
- DOI
- https://doi.org/10.1038/s41467-022-32289-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Children with type 1 diabetes (T1D) are at risk for reduced cognitive ability and atypical brain development. This study shows that brain and cognitive measures can be improved in adolescents with T1D using a semi-automated insulin delivery system.
