Structural basis of terephthalate recognition by solute binding protein TphC

Trishnamoni Gautom; Dharmendra Dheeman; Colin Levy; Thomas Butterfield; Guadalupe Alvarez Gonzalez; Philip Le Roy; Lewis Caiger; Karl Fisher; Linus Johannissen; Neil Dixon

doi:10.1038/s41467-021-26508-0

Nature Communications (Oct 2021)

Structural basis of terephthalate recognition by solute binding protein TphC

Trishnamoni Gautom,
Dharmendra Dheeman,
Colin Levy,
Thomas Butterfield,
Guadalupe Alvarez Gonzalez,
Philip Le Roy,
Lewis Caiger,
Karl Fisher,
Linus Johannissen,
Neil Dixon

Affiliations

Trishnamoni Gautom: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Dharmendra Dheeman: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Colin Levy: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Thomas Butterfield: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Guadalupe Alvarez Gonzalez: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Philip Le Roy: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Lewis Caiger: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Karl Fisher: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Linus Johannissen: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester
Neil Dixon: Manchester Institute of Biotechnology (MIB) and Department of Chemistry, The University of Manchester

DOI: https://doi.org/10.1038/s41467-021-26508-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The presence of the gene encoding the solute binding protein TphC has been shown to permit the uptake of terephthalate (TPA), which is the breakdown product of Polyethylene terephthalate (PET) plastic. Here the authors present a structural characterization of TphC in both open and TPA-bound closed conformations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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