Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Zhipeng Fang; Mingjie Fan; Dongqiang Yuan; Lihua Jin; Yangmeng Wang; Lili Ding; Senlin Xu; Jui Tu; Eryun Zhang; Xiwei Wu; Zhen Bouman Chen; Wendong Huang

doi:10.1038/s42003-023-04483-0

Communications Biology (Jan 2023)

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Zhipeng Fang,
Mingjie Fan,
Dongqiang Yuan,
Lihua Jin,
Yangmeng Wang,
Lili Ding,
Senlin Xu,
Jui Tu,
Eryun Zhang,
Xiwei Wu,
Zhen Bouman Chen,
Wendong Huang

Affiliations

Zhipeng Fang: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Mingjie Fan: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Dongqiang Yuan: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Lihua Jin: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Yangmeng Wang: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Lili Ding: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Senlin Xu: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Jui Tu: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Eryun Zhang: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Xiwei Wu: Integrated Genomic Core, City of Hope National Medical Center
Zhen Bouman Chen: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center
Wendong Huang: Department of Diabetes Complications and Metabolism, Arthur Riggs-Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center

DOI: https://doi.org/10.1038/s42003-023-04483-0
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 10

Abstract

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A hepatic lncRNA Gm19619, which is repressed by vertical sleeve gastrectomy but upregulated by obesity and fasting, regulates gluconeogenesis and lipid metabolism in mice through Foxo1-G6pc/Pck1 and Lepr signaling pathway respectively.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal