Levofloxacin Treatment Failure in Haemophilus influenzae Pneumonia

Abstract

We describe the first case of failure of oral levofloxacin treatment of community-acquired pneumonia caused by Haemophilus influenzae. The strain showed cross-resistance to fluoroquinolones and carried four mutations in quinolone resistance–determining regions of DNA gyrase and topoisomerase IV genes.

Keywords

• anti-infective agents fluoroquinolone
• bacterial pneumonia
• drug resistance bacterial
• drug resistance microbial
• Haemonphilus influenzae
• Haemophilus infections