Nature Communications (Nov 2019)
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
- Alice Koenig,
- Chien-Chia Chen,
- Antoine Marçais,
- Thomas Barba,
- Virginie Mathias,
- Antoine Sicard,
- Maud Rabeyrin,
- Maud Racapé,
- Jean-Paul Duong-Van-Huyen,
- Patrick Bruneval,
- Alexandre Loupy,
- Sébastien Dussurgey,
- Stéphanie Ducreux,
- Vannary Meas-Yedid,
- Jean-Christophe Olivo-Marin,
- Héléna Paidassi,
- Romain Guillemain,
- Jean-Luc Taupin,
- Jasper Callemeyn,
- Emmanuel Morelon,
- Antonino Nicoletti,
- Béatrice Charreau,
- Valérie Dubois,
- Maarten Naesens,
- Thierry Walzer,
- Thierry Defrance,
- Olivier Thaunat
Affiliations
- Alice Koenig
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Chien-Chia Chen
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Antoine Marçais
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Thomas Barba
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Virginie Mathias
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Antoine Sicard
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Maud Rabeyrin
- Hospices Civils de Lyon, Department of Pathology
- Maud Racapé
- Paris Translational Research Centre for Organ Transplantation, Paris Descartes University
- Jean-Paul Duong-Van-Huyen
- Paris Translational Research Centre for Organ Transplantation, Paris Descartes University
- Patrick Bruneval
- Paris Translational Research Centre for Organ Transplantation, Paris Descartes University
- Alexandre Loupy
- Paris Translational Research Centre for Organ Transplantation, Paris Descartes University
- Sébastien Dussurgey
- SFR Biosciences (UMS3444/CNRS, US8/Inserm, ENS de Lyon, UCBL)
- Stéphanie Ducreux
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Vannary Meas-Yedid
- Unité d’Analyse d’Images Biologiques, Pasteur Institut
- Jean-Christophe Olivo-Marin
- Unité d’Analyse d’Images Biologiques, Pasteur Institut
- Héléna Paidassi
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Romain Guillemain
- Assistance Publique - Hôpitaux de Paris, Georges Pompidou Hospital, Cardiology and Heart Transplant Department
- Jean-Luc Taupin
- Assistance Publique - Hôpitaux de Paris, Immunology and HLA Laboratory, Saint-Louis Hospital
- Jasper Callemeyn
- Department of Microbiology and Immunology, KU Leuven, University of Leuven
- Emmanuel Morelon
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Antonino Nicoletti
- Paris Diderot University
- Béatrice Charreau
- French National Institute of Health and Medical Research (Inserm) UMR1064
- Valérie Dubois
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Maarten Naesens
- Department of Microbiology and Immunology, KU Leuven, University of Leuven
- Thierry Walzer
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Thierry Defrance
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- Olivier Thaunat
- CIRI, INSERM U1111, Université Claude Bernard Lyon I, CNRS UMR5308, Ecole Normale Supérieure de Lyon, Univ. Lyon
- DOI
- https://doi.org/10.1038/s41467-019-13113-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejection, a pathology that is preventable by mTOR inhibition.
