Pharmacogenetic Tests in the Nephrological Clinic

Abstract

Selection of antihypertensive agents using pharmacogenetic tests and individual tolerance is essential in practical nephrology. Antihypertensive first-line drugs are metabolized through various CYP isoforms (CYP2D6, CYP2C9, CYP2C19 and CYP3A4/5). These isoforms are the most significant for the patient in response to the drug. From a clinical point of view, it is important to establish the slow metabolizers, because in them we should use other doses of antihypertensive drugs that differ from the standard ones.

Keywords

• antihypertensive drugs in nephrology
• pharmacogenetic tests
• CYP isoforms (CYP2D6
• CYP2C9
• CYP2C19
• ­CYP3A4/5)
• titration of the drug