Frontiers in Neurology (Jun 2022)
Analysis of Side Effects Following Vaccination Against COVID-19 Among Individuals With Multiple Sclerosis Treated With DMTs in Poland
- Agata Czarnowska,
- Joanna Tarasiuk,
- Olga Zajkowska,
- Marcin Wnuk,
- Monika Marona,
- Klaudia Nowak,
- Agnieszka Słowik,
- Anna Jamroz-Wiśniewska,
- Konrad Rejdak,
- Beata Lech,
- Małgorzata Popiel,
- Iwona Rościszewska-Żukowska,
- Adam Perenc,
- Halina Bartosik-Psujek,
- Mariola Świderek-Matysiak,
- Małgorzata Siger,
- Agnieszka Ciach,
- Agata Walczak,
- Anna Jurewicz,
- Mariusz Stasiołek,
- Karolina Kania,
- Klara Dyczkowska,
- Alicja Kalinowska-Łyszczarz,
- Weronika Galus,
- Anna Walawska-Hrycek,
- Ewa Krzystanek,
- Justyna Chojdak-Łukasiewicz,
- Jakub Ubysz,
- Anna Pokryszko-Dragan,
- Katarzyna Kapica-Topczewska,
- Monika Chorąży,
- Marcin Bazylewicz,
- Anna Mirończuk,
- Joanna Kulikowska,
- Jan Kochanowicz,
- Marta Białek,
- Małgorzata Stolarz,
- Katarzyna Kubicka-Bączyk,
- Natalia Niedziela,
- Paweł Warmus,
- Monika Adamczyk-Sowa,
- Aleksandra Podlecka-Piçtowska,
- Monika Nojszewska,
- Beata Zakrzewska-Pniewska,
- Elżbieta Jasińska,
- Elżbieta Jasińska,
- Jacek Zaborski,
- Marta Milewska-Jȩdrzejczak,
- Jacek Zwiernik,
- Jacek Zwiernik,
- Beata Zwiernik,
- Beata Zwiernik,
- Andrzej Potemkowski,
- Waldemar Brola,
- Alina Kułakowska
Affiliations
- Agata Czarnowska
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- Joanna Tarasiuk
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- Olga Zajkowska
- Faculty of Economic Sciences, University of Warsaw, Warsaw, Poland
- Marcin Wnuk
- Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
- Monika Marona
- Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
- Klaudia Nowak
- Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
- Agnieszka Słowik
- Department of Neurology, Jagiellonian University Medical College, Krakow, Poland
- Anna Jamroz-Wiśniewska
- Department of Neurology, Medical University of Lublin, Lublin, Poland
- Konrad Rejdak
- Department of Neurology, Medical University of Lublin, Lublin, Poland
- Beata Lech
- Neurology Clinic With Brain Stroke Sub-Unit, Clinical Hospital No. 2 in Rzeszow, Lwowska, Poland
- Małgorzata Popiel
- Neurology Clinic With Brain Stroke Sub-Unit, Clinical Hospital No. 2 in Rzeszow, Lwowska, Poland
- Iwona Rościszewska-Żukowska
- Department of Neurology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland
- Adam Perenc
- Neurology Clinic With Brain Stroke Sub-Unit, Clinical Hospital No. 2 in Rzeszow, Lwowska, Poland
- Halina Bartosik-Psujek
- Department of Neurology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland
- Mariola Świderek-Matysiak
- Department of Neurology, Medical University of Lodz, Łódz, Poland
- Małgorzata Siger
- Department of Neurology, Medical University of Lodz, Łódz, Poland
- Agnieszka Ciach
- Department of Neurology, Medical University of Lodz, Łódz, Poland
- Agata Walczak
- Department of Neurology, Medical University of Lodz, Łódz, Poland
- Anna Jurewicz
- Department of Neurology, Medical University of Lodz, Łódz, Poland
- Mariusz Stasiołek
- Department of Neurology, Medical University of Lodz, Łódz, Poland
- Karolina Kania
- Department of Neurology, Poznan University of Medical Sciences, Poznań, Poland
- Klara Dyczkowska
- Department of Neurology, Poznan University of Medical Sciences, Poznań, Poland
- Alicja Kalinowska-Łyszczarz
- Division of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Poznań, Poland
- Weronika Galus
- 0Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
- Anna Walawska-Hrycek
- 0Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
- Ewa Krzystanek
- 0Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
- Justyna Chojdak-Łukasiewicz
- 1Department of Neurology, Wroclaw Medical University, Wroclaw, Poland
- Jakub Ubysz
- 1Department of Neurology, Wroclaw Medical University, Wroclaw, Poland
- Anna Pokryszko-Dragan
- 1Department of Neurology, Wroclaw Medical University, Wroclaw, Poland
- Katarzyna Kapica-Topczewska
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- Monika Chorąży
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- Marcin Bazylewicz
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- Anna Mirończuk
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- Joanna Kulikowska
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- Jan Kochanowicz
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- Marta Białek
- 2Department of Neurology, Regional Specialised Hospital No. 4 in Bytom, Bytom, Poland
- Małgorzata Stolarz
- 2Department of Neurology, Regional Specialised Hospital No. 4 in Bytom, Bytom, Poland
- Katarzyna Kubicka-Bączyk
- 3Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland
- Natalia Niedziela
- 3Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland
- Paweł Warmus
- 3Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland
- Monika Adamczyk-Sowa
- 3Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland
- Aleksandra Podlecka-Piçtowska
- 4Department of Neurology, Medical University of Warsaw, Warsaw, Poland
- Monika Nojszewska
- 4Department of Neurology, Medical University of Warsaw, Warsaw, Poland
- Beata Zakrzewska-Pniewska
- 4Department of Neurology, Medical University of Warsaw, Warsaw, Poland
- Elżbieta Jasińska
- 5Jan Kochanowski University, Collegium Medicum, Kielce, Poland
- Elżbieta Jasińska
- 6Clinical Center, Resmedica, Kielce, Poland
- Jacek Zaborski
- 7Department of Neurology and Neurorehabilitation, Miedzyleski Szpital Specjalistyczny, Warsaw, Poland
- Marta Milewska-Jȩdrzejczak
- 8Department of Neurology and Ischemic Strokes, Medical University of Lodz, Lodz, Poland
- Jacek Zwiernik
- 9Neurology Ward, Provincial Specialist Hospital, Olsztyn, Poland
- Jacek Zwiernik
- 0Department of Neurology, University of Warmia and Mazury, Olsztyn, Poland
- Beata Zwiernik
- 1Department of Neurology, University of Warmia and Mazury, Olsztyn, Poland
- Beata Zwiernik
- 2Clinic of Neurology, University of Warmia and Mazury, Olsztyn, Poland
- Andrzej Potemkowski
- 3Department of Clinical Psychology and Psychoprophylaxis, University of Szczecin, Szczecin, Poland
- Waldemar Brola
- 4Department of Neurology, Specialist Hospital in Końskie, Collegium Medicum, Jan Kochanowski University in Kielce, Kielce, Poland
- Alina Kułakowska
- Department of Neurology, Medical University of Białystok, Białystok, Poland
- DOI
- https://doi.org/10.3389/fneur.2022.913283
- Journal volume & issue
-
Vol. 13
Abstract
Background and ObjectivesSince vaccination against COVID-19 is available for over a year and the population of immunized individuals with autoimmune disorders is higher than several months before, an evaluation of safety and registered adverse events can be made. We conducted a large study of side effects following the COVID-19 vaccine among patients with multiple (MS) sclerosis treated with disease-modifying therapies (DMTs) and analyzed factors predisposing for particular adverse events.MethodsWe gathered data of individuals with MS treated with DMTs from 19 Polish MS Centers, who reported at least one adverse event following COVID-19 vaccination. The information was obtained by neurologists using a questionnaire. The same questionnaire was used at all MS Centers. To assess the relevance of reported adverse events, we used Fisher's exact test, t-test, and U-Menn-Whutney test.ResultsA total of 1,668 patients with MS and reports of adverse events after COVID-19 vaccination were finally included in the study. Besides one case marked as “red flag”, all adverse events were classified as mild. Pain at the injection site was the most common adverse event, with a greater frequency after the first dose. Pain at the injection site was significantly more frequent after the first dose among individuals with a lower disability (EDSS ≤2). The reported adverse events following immunization did not differ over sex. According to age, pain at the injection site was more common among individuals between 30 and 40 years old, only after the first vaccination dose. None of the DMTs predisposed for particular side effects.ConclusionsAccording to our findings, vaccination against COVID-19 among patients with MS treated with DMTs is safe. Our study can contribute to reducing hesitancy toward vaccination among patients with MS.
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