OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling

Liang Ding; Yong Fu; Nisha Zhu; Mengxiang Zhao; Zhuang Ding; Xiaoxin Zhang; Yuxian Song; Yue Jing; Qian Zhang; Sheng Chen; Xiaofeng Huang; Lorraine A O’Reilly; John Silke; Qingang Hu; Yanhong Ni

doi:10.1038/s41467-022-32787-y

Nature Communications (Aug 2022)

OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling

Liang Ding,
Yong Fu,
Nisha Zhu,
Mengxiang Zhao,
Zhuang Ding,
Xiaoxin Zhang,
Yuxian Song,
Yue Jing,
Qian Zhang,
Sheng Chen,
Xiaofeng Huang,
Lorraine A O’Reilly,
John Silke,
Qingang Hu,
Yanhong Ni

Affiliations

Liang Ding: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Yong Fu: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Nisha Zhu: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Mengxiang Zhao: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Zhuang Ding: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Xiaoxin Zhang: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Yuxian Song: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Yue Jing: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Qian Zhang: Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University
Sheng Chen: Department of Oral Pathology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Xiaofeng Huang: Department of Oral Pathology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Lorraine A O’Reilly: The Walter and Eliza Hall Institute of Medical Research
John Silke: The Walter and Eliza Hall Institute of Medical Research
Qingang Hu: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
Yanhong Ni: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University

DOI: https://doi.org/10.1038/s41467-022-32787-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Worst pattern of invasion (WPOI) is a parameter used to quantify tumor invasiveness of oral squamous cell carcinoma (OSCC). Here the authors show that a fibroblast subset characterized by the expression of the oxytocin receptor is enriched in highly invasive WPOI 4-5 OSCC tumors and can be targeted to reduce the desmoplastic stroma and tumor metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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