Structural analysis of human CEACAM1 oligomerization

Amit K. Gandhi; Zhen-Yu J. Sun; Yu-Hwa Huang; Walter M. Kim; Chao Yang; Gregory A. Petsko; Nicole Beauchemin; Richard S. Blumberg

doi:10.1038/s42003-022-03996-4

Communications Biology (Sep 2022)

Structural analysis of human CEACAM1 oligomerization

Amit K. Gandhi,
Zhen-Yu J. Sun,
Yu-Hwa Huang,
Walter M. Kim,
Chao Yang,
Gregory A. Petsko,
Nicole Beauchemin,
Richard S. Blumberg

Affiliations

Amit K. Gandhi: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Zhen-Yu J. Sun: Department of Cancer Biology, Dana-Farber Cancer Institute
Yu-Hwa Huang: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Walter M. Kim: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Chao Yang: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Gregory A. Petsko: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School
Nicole Beauchemin: Rosalind and Morris Goodman Cancer Institute, McGill University
Richard S. Blumberg: Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s42003-022-03996-4
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

Read online

The crystal structure of human CEACAM1 IgV oligomer and structural analyses provide insight into higher-order oligomerization involving GFCC’ face-mediated homodimerization, flexible ABED interfaces, and dynamic metal-ion bridging.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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