Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes

Shihua Song; Jing Zhou; Chunling Fu; Shengming Ma

doi:10.1038/s41467-018-07908-1

Nature Communications (Jan 2019)

Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes

Shihua Song,
Jing Zhou,
Chunling Fu,
Shengming Ma

Affiliations

Shihua Song: Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University
Jing Zhou: Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University
Chunling Fu: Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University
Shengming Ma: Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University

DOI: https://doi.org/10.1038/s41467-018-07908-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Highly enantioselective synthesis of allenes has been relying, so far, on the steric hindrance of substrates. Here the authors achieve excellent stereocontrol in the synthesis of chiral allenes with a palladium-DTBM-SEGPHOS catalytic system in a non-substrate-dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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