Natural exosome-like nanoparticles derived from ancient medicinal insect Periplaneta americana L. as a novel diabetic wound healing accelerator

Abstract

Highlights Periplaneta americana L. derived exosome-like nanoparticles (PA-ELNs) as a novel wound healing accelerator was isolated and proved. Protein and small RNA components in PA-ELNs were characterized by omics technology. PA-ELNs remarkably accelerated diabetic wound healing, and were involved in anti-inflammatory, re-epithelialization and autophagy regulation in this process.

Keywords

• Periplaneta americana (L.)
• Exosome-like nanoparticles
• Proteomics
• Small RNA
• Wound healing
• Autophagy