Emerging Infectious Diseases (May 2021)

Whole-Genome Sequencing of Shiga Toxin–Producing Escherichia coli OX18 from a Fatal Hemolytic Uremic Syndrome Case

  • Kenichi Lee,
  • Atsushi Iguchi,
  • Kazuhiro Uda,
  • Sohshi Matsumura,
  • Isao Miyairi,
  • Kenji Ishikura,
  • Makoto Ohnishi,
  • Junji Seto,
  • Kanako Ishikawa,
  • Noriko Konishi,
  • Hiromi Obata,
  • Ichiro Furukawa,
  • Hiromi Nagaoka,
  • Hirotaka Morinushi,
  • Natsuki Hama,
  • Ryohei Nomoto,
  • Hiroshi Nakajima,
  • Hideaki Kariya,
  • Mitsuhiro Hamasaki,
  • Sunao Iyoda

DOI
https://doi.org/10.3201/eid2705.204162
Journal volume & issue
Vol. 27, no. 5
pp. 1509 – 1512

Abstract

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We report a fatal case of hemolytic uremic syndrome with urinary tract infection in Japan caused by Shiga toxin–producing Escherichia coli. We genotypically identified the isolate as OX18:H2. Whole-genome sequencing revealed 3 potentially pathogenic lineages (OX18:H2, H19, and H34) that have been continuously isolated in Japan.

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