Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing

George R. R. Bell; Esther Rincón; Emel Akdoğan; Sean R. Collins

doi:10.1038/s41467-021-26371-z

Nature Communications (Nov 2021)

Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing

George R. R. Bell,
Esther Rincón,
Emel Akdoğan,
Sean R. Collins

Affiliations

George R. R. Bell: Department of Microbiology and Molecular Genetics, University of California, Davis
Esther Rincón: Department of Microbiology and Molecular Genetics, University of California, Davis
Emel Akdoğan: Department of Microbiology and Molecular Genetics, University of California, Davis
Sean R. Collins: Department of Microbiology and Molecular Genetics, University of California, Davis

DOI: https://doi.org/10.1038/s41467-021-26371-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Here the authors use optogenetic tools to directly measure spatial signal processing in leukocyte chemotaxis. Their results reveal the importance of multiple negative feedback loops for maintaining spatial information in chemotaxis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal