Role of influenza A virus NP acetylation on viral growth and replication

Sebastian Giese; Kevin Ciminski; Hardin Bolte; Étori Aguiar Moreira; Seema Lakdawala; Zehan Hu; Quinnlan David; Larissa Kolesnikova; Veronika Götz; Yongxu Zhao; Jörn Dengjel; Y. Eugene Chin; Ke Xu; Martin Schwemmle

doi:10.1038/s41467-017-01112-3

Nature Communications (Nov 2017)

Role of influenza A virus NP acetylation on viral growth and replication

Sebastian Giese,
Kevin Ciminski,
Hardin Bolte,
Étori Aguiar Moreira,
Seema Lakdawala,
Zehan Hu,
Quinnlan David,
Larissa Kolesnikova,
Veronika Götz,
Yongxu Zhao,
Jörn Dengjel,
Y. Eugene Chin,
Ke Xu,
Martin Schwemmle

Affiliations

Sebastian Giese: Institute of Virology, Medical Center University of Freiburg
Kevin Ciminski: Institute of Virology, Medical Center University of Freiburg
Hardin Bolte: Institute of Virology, Medical Center University of Freiburg
Étori Aguiar Moreira: Institute of Virology, Medical Center University of Freiburg
Seema Lakdawala: Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
Zehan Hu: Department of Dermatology, Medical Center, University of Freiburg
Quinnlan David: Institute of Virology, Medical Center University of Freiburg
Larissa Kolesnikova: Institute of Virology, Philipps-Universität Marburg
Veronika Götz: Institute of Virology, Medical Center University of Freiburg
Yongxu Zhao: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Jörn Dengjel: Department of Dermatology, Medical Center, University of Freiburg
Y. Eugene Chin: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Ke Xu: Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Martin Schwemmle: Institute of Virology, Medical Center University of Freiburg

DOI: https://doi.org/10.1038/s41467-017-01112-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and virion release.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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