OVEREXPRESSION OF IGF1 PROGNOSTIC FACTOR IN CHILDHOOD OSTEOSARCOMAS

Abstract

Osteosarcoma is a highly malignant intraosseous tumour formed by tumour cells producing osteoid, bone or chondroid material (1). Considering the reserved prognosis of this neoplasia, we attempted to identify and analyze some biomarkers in order to perform a multivariate analysis and to assess the predictive power of the evolution. In search of new and reliable biomarkers we studied IGF1 overexpression in osteosarcoma. IGF1 is an insulin-like polypeptide hormone with a vital role in normal bone development by stimulating bone growth. We therefore decided to investigate the role of these biomarkers in osteosarcoma. For this purpose we analyzed 46 samples from 27 patients diagnosed with Osteosarcoma in the period 2017-2021 in the Children’s Emergency Clinical Hospital “Sf.Maria”, Iasi.