Nature Communications (Jun 2021)
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis
- Denise Beckmann,
- Anja Römer-Hillmann,
- Annika Krause,
- Uwe Hansen,
- Corinna Wehmeyer,
- Johanna Intemann,
- David J. J. de Gorter,
- Berno Dankbar,
- Jan Hillen,
- Marianne Heitzmann,
- Isabell Begemann,
- Milos Galic,
- Toni Weinhage,
- Dirk Foell,
- Rizi Ai,
- Joachim Kremerskothen,
- Hans P. Kiener,
- Sylvia Müller,
- Thomas Kamradt,
- Christopher Schröder,
- Elsa Leitão,
- Bernhard Horsthemke,
- Philip Rosenstiel,
- Karl Nordström,
- Gilles Gasparoni,
- Nina Gasparoni,
- Jörn Walter,
- Na Li,
- Xinyi Yang,
- Ho-Ryun Chung,
- Hermann Pavenstädt,
- Nico Lindemann,
- Hans J. Schnittler,
- Wei Wang,
- Gary S. Firestein,
- Thomas Pap,
- Adelheid Korb-Pap
Affiliations
- Denise Beckmann
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Anja Römer-Hillmann
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Annika Krause
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Uwe Hansen
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Corinna Wehmeyer
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Johanna Intemann
- Institute of Musculoskeletal Medicine, University Hospital Münster
- David J. J. de Gorter
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Berno Dankbar
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Jan Hillen
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Marianne Heitzmann
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Isabell Begemann
- Institute of Medical Physics and Biophysics, University of Münster
- Milos Galic
- Institute of Medical Physics and Biophysics, University of Münster
- Toni Weinhage
- Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster
- Dirk Foell
- Department of Pediatric Rheumatology and Immunology, University Children’s Hospital Münster
- Rizi Ai
- Department of Chemistry and Biochemistry, 9500 Gilman Drive, UC San Diego
- Joachim Kremerskothen
- Department of Nephrology and Rheumatology, Internal Medicine D, University Hospital Münster
- Hans P. Kiener
- Department of Medicine III, Division of Rheumatology, Medical University of Vienna
- Sylvia Müller
- Institute for Immunology, Jena University Hospital, Friedrich Schiller University
- Thomas Kamradt
- Institute for Immunology, Jena University Hospital, Friedrich Schiller University
- Christopher Schröder
- Genome Informatics, Institute of Human Genetics, University of Duisburg-Essen
- Elsa Leitão
- Institute of Human Genetics, University Hospital of Essen, University of Duisburg-Essen
- Bernhard Horsthemke
- Institute of Human Genetics, University Hospital of Essen, University of Duisburg-Essen
- Philip Rosenstiel
- Institute of Clinical Molecular Biology, University of Kiel
- Karl Nordström
- Department of Genetics/Epigenetics, Saarland University
- Gilles Gasparoni
- Department of Genetics/Epigenetics, Saarland University
- Nina Gasparoni
- Department of Genetics/Epigenetics, Saarland University
- Jörn Walter
- Department of Genetics/Epigenetics, Saarland University
- Na Li
- Max Planck Institute for Molecular Genetics, Otto-Warburg-Laboratories
- Xinyi Yang
- Max Planck Institute for Molecular Genetics, Otto-Warburg-Laboratories
- Ho-Ryun Chung
- Max Planck Institute for Molecular Genetics, Otto-Warburg-Laboratories
- Hermann Pavenstädt
- Department of Nephrology and Rheumatology, Internal Medicine D, University Hospital Münster
- Nico Lindemann
- Institute of Anatomy and Vascular Biology, University of Münster
- Hans J. Schnittler
- Institute of Anatomy and Vascular Biology, University of Münster
- Wei Wang
- Department of Chemistry and Biochemistry, 9500 Gilman Drive, UC San Diego
- Gary S. Firestein
- Division of Rheumatology, Allergy and Immunology, 9500 Gilman Drive, UCSD School of Medicine
- Thomas Pap
- Institute of Musculoskeletal Medicine, University Hospital Münster
- Adelheid Korb-Pap
- Institute of Musculoskeletal Medicine, University Hospital Münster
- DOI
- https://doi.org/10.1038/s41467-021-23706-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in a mouse model of inflammatory arthritis.
