Nature Communications (May 2017)
MICU1 drives glycolysis and chemoresistance in ovarian cancer
- Prabir K. Chakraborty,
- Soumyajit Banerjee Mustafi,
- Xunhao Xiong,
- Shailendra Kumar Dhar Dwivedi,
- Vasyl Nesin,
- Sounik Saha,
- Min Zhang,
- Danny Dhanasekaran,
- Muralidharan Jayaraman,
- Robert Mannel,
- Kathleen Moore,
- Scott McMeekin,
- Da Yang,
- Rosemary Zuna,
- Kai Ding,
- Leonidas Tsiokas,
- Resham Bhattacharya,
- Priyabrata Mukherjee
Affiliations
- Prabir K. Chakraborty
- Department of Pathology, The University of Oklahoma Health Sciences Center
- Soumyajit Banerjee Mustafi
- Department of Obstetrics and Gynecology, The University of Oklahoma Health Sciences Center
- Xunhao Xiong
- Department of Pathology, The University of Oklahoma Health Sciences Center
- Shailendra Kumar Dhar Dwivedi
- Department of Obstetrics and Gynecology, The University of Oklahoma Health Sciences Center
- Vasyl Nesin
- Department of Cell Biology, The University of Oklahoma Health Sciences Center
- Sounik Saha
- Department of Pathology, The University of Oklahoma Health Sciences Center
- Min Zhang
- Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy
- Danny Dhanasekaran
- Department of Cell Biology, The University of Oklahoma Health Sciences Center
- Muralidharan Jayaraman
- Department of Cell Biology, The University of Oklahoma Health Sciences Center
- Robert Mannel
- Department of Obstetrics and Gynecology, The University of Oklahoma Health Sciences Center
- Kathleen Moore
- Department of Obstetrics and Gynecology, The University of Oklahoma Health Sciences Center
- Scott McMeekin
- Department of Obstetrics and Gynecology, The University of Oklahoma Health Sciences Center
- Da Yang
- Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy
- Rosemary Zuna
- Department of Pathology, The University of Oklahoma Health Sciences Center
- Kai Ding
- College of Public Health, The University of Oklahoma Health Sciences Center
- Leonidas Tsiokas
- Department of Cell Biology, The University of Oklahoma Health Sciences Center
- Resham Bhattacharya
- Department of Obstetrics and Gynecology, The University of Oklahoma Health Sciences Center
- Priyabrata Mukherjee
- Department of Pathology, The University of Oklahoma Health Sciences Center
- DOI
- https://doi.org/10.1038/ncomms14634
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.
