Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity

Deyong Jia; Zhicheng Zhou; Oh-Joon Kwon; Li Zhang; Xing Wei; Yiqun Zhang; Mingyang Yi; Martine P. Roudier; Mary C. Regier; Ruth Dumpit; Peter S. Nelson; Mark Headley; Lawrence True; Daniel W. Lin; Colm Morrissey; Chad J. Creighton; Li Xin

doi:10.1038/s41467-022-34665-z

Nature Communications (Nov 2022)

Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity

Deyong Jia,
Zhicheng Zhou,
Oh-Joon Kwon,
Li Zhang,
Xing Wei,
Yiqun Zhang,
Mingyang Yi,
Martine P. Roudier,
Mary C. Regier,
Ruth Dumpit,
Peter S. Nelson,
Mark Headley,
Lawrence True,
Daniel W. Lin,
Colm Morrissey,
Chad J. Creighton,
Li Xin

Affiliations

Deyong Jia: Department of Urology, University of Washington
Zhicheng Zhou: Department of Urology, University of Washington
Oh-Joon Kwon: Department of Urology, University of Washington
Li Zhang: Department of Urology, University of Washington
Xing Wei: Department of Urology, University of Washington
Yiqun Zhang: Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
Mingyang Yi: Department of Biochemistry, University of Washington
Martine P. Roudier: Department of Urology, University of Washington
Mary C. Regier: Institute of Stem Cell and Regenerative Medicine, University of Washington
Ruth Dumpit: Division of Human Biology, Fred Hutchinson Cancer Research Center
Peter S. Nelson: Division of Human Biology, Fred Hutchinson Cancer Research Center
Mark Headley: Division of Human Biology, Fred Hutchinson Cancer Research Center
Lawrence True: Department of Laboratory Medicine and Pathology, University of Washington
Daniel W. Lin: Department of Urology, University of Washington
Colm Morrissey: Department of Urology, University of Washington
Chad J. Creighton: Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
Li Xin: Department of Urology, University of Washington

DOI: https://doi.org/10.1038/s41467-022-34665-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

Read online

Forkhead transcription factor FoxF2 plays a crucial role in the development of organs derived from primitive gut. Here the authors show that reduction of Foxf2 expression in stromal cells is associated with high grade prostate cancer and that increasing prostatic stromal Foxf2 sensitizes prostate cancer to immune checkpoint blockade.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal