Nature Communications (Oct 2018)

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

  • Alfredo Cabrera-Orefice,
  • Etienne Galemou Yoga,
  • Christophe Wirth,
  • Karin Siegmund,
  • Klaus Zwicker,
  • Sergio Guerrero-Castillo,
  • Volker Zickermann,
  • Carola Hunte,
  • Ulrich Brandt

DOI
https://doi.org/10.1038/s41467-018-06955-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

Read online

Proton pumping of mitochondrial complex I depends on the reduction of ubiquinone but the molecular mechanism of energy conversion is unclear. Here, the authors provide structural and biochemical evidence showing that movement of loop TMH1-2 in complex I subunit ND3 is required to drive proton pumping.