Frontiers in Microbiology (Mar 2021)

Molecular Characteristics, Antigenicity, Pathogenicity, and Zoonotic Potential of a H3N2 Canine Influenza Virus Currently Circulating in South China

  • Meihua Wu,
  • Meihua Wu,
  • Meihua Wu,
  • Meihua Wu,
  • Meihua Wu,
  • Rongsheng Su,
  • Rongsheng Su,
  • Yongxia Gu,
  • Yongxia Gu,
  • Yongxia Gu,
  • Yongxia Gu,
  • Yongxia Gu,
  • Yanan Yu,
  • Yanan Yu,
  • Yanan Yu,
  • Yanan Yu,
  • Yanan Yu,
  • Shuo Li,
  • Shuo Li,
  • Shuo Li,
  • Shuo Li,
  • Shuo Li,
  • Huapeng Sun,
  • Huapeng Sun,
  • Huapeng Sun,
  • Huapeng Sun,
  • Huapeng Sun,
  • Liangqi Pan,
  • Liangqi Pan,
  • Liangqi Pan,
  • Liangqi Pan,
  • Liangqi Pan,
  • Xinxin Cui,
  • Xinxin Cui,
  • Xinxin Cui,
  • Xinxin Cui,
  • Xinxin Cui,
  • Xuhui Zhu,
  • Xuhui Zhu,
  • Xuhui Zhu,
  • Xuhui Zhu,
  • Xuhui Zhu,
  • Qingzhou Yang,
  • Qingzhou Yang,
  • Qingzhou Yang,
  • Qingzhou Yang,
  • Qingzhou Yang,
  • Yanwei Liu,
  • Yanwei Liu,
  • Yanwei Liu,
  • Yanwei Liu,
  • Yanwei Liu,
  • Fengxiang Xu,
  • Fengxiang Xu,
  • Fengxiang Xu,
  • Fengxiang Xu,
  • Fengxiang Xu,
  • Mingliang Li,
  • Mingliang Li,
  • Mingliang Li,
  • Mingliang Li,
  • Mingliang Li,
  • Yang Liu,
  • Yang Liu,
  • Yang Liu,
  • Yang Liu,
  • Yang Liu,
  • Xiaoyun Qu,
  • Xiaoyun Qu,
  • Xiaoyun Qu,
  • Xiaoyun Qu,
  • Xiaoyun Qu,
  • Jie Wu,
  • Ming Liao,
  • Ming Liao,
  • Ming Liao,
  • Ming Liao,
  • Ming Liao,
  • Hailiang Sun,
  • Hailiang Sun,
  • Hailiang Sun,
  • Hailiang Sun,
  • Hailiang Sun

DOI
https://doi.org/10.3389/fmicb.2021.628979
Journal volume & issue
Vol. 12

Abstract

Read online

Canine influenza viruses (CIVs) could be a source of influenza viruses which infect humans because canine are important companion pets. To assess the potential risk of H3N2 CIVs currently circulating in southern China to public health, biological characteristics of A/canine/Guangdong/DY1/2019 (CADY1/2019) were detected. CADY1/2019 bound to both avian-type and human-type receptors. CADY1/2019 had a similar pH value for HA protein fusion to human viruses, but its antigenicity was obviously different from those of current human H3N2 influenza viruses (IVs) or the vaccine strains recommended in the North hemisphere. CADY1/2019 effectively replicated in the respiratory tract and was transmitted by physical contact among guinea pigs. Compared to human H3N2 IV, CADY1/2019 exhibited higher replication in MDCK, A549, 3D4/21, ST, and PK15 cells. Sequence analysis indicated that CADY1/2019 is an avian-origin virus, and belongs to the novel clade and has acquired many adaptation mutations to infect other mammals, including human. Taken together, currently circulating H3N2 CIVs have a zoonotic potential, and there is a need for strengthening surveillance and monitoring of their pathogenicity.

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