Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization

Abstract

Here, the authors employ Raman-Activated Cell Sorting (RACS) and metagenomics to identify organisms that can forage on O-glycan monosaccharides in the mouse gut, which they use to construct a bacterial consortium able to reduce Clostridioides difficile colonization based on competition for mucosal sugars.