Nature Communications (Sep 2019)

PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation

  • Joaquin Navajas Acedo,
  • Matthew G. Voas,
  • Richard Alexander,
  • Thomas Woolley,
  • Jay R. Unruh,
  • Hua Li,
  • Cecilia Moens,
  • Tatjana Piotrowski

DOI
https://doi.org/10.1038/s41467-019-12005-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Planar cell polarity (PCP) regulates hair cell orientation in the zebrafish lateral line. Here, the authors show that mutating Wnt pathway genes (wnt11f1, fzd7a/b, and gpc4) causes concentric hair cell patterns not regulated by PCP, thus showing PCP/Wnt pathway genes have different consequences on hair cell orientation.