Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane

Ben D. Richardson; Kaustuv Saha; Danielle Krout; Elizabeth Cabrera; Bruce Felts; L. Keith Henry; Jarod Swant; Mu-Fa Zou; Amy Hauck Newman; Habibeh Khoshbouei

doi:10.1038/ncomms10423

Nature Communications (Jan 2016)

Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane

Ben D. Richardson,
Kaustuv Saha,
Danielle Krout,
Elizabeth Cabrera,
Bruce Felts,
L. Keith Henry,
Jarod Swant,
Mu-Fa Zou,
Amy Hauck Newman,
Habibeh Khoshbouei

Affiliations

Ben D. Richardson: Department of Neuroscience, Evelyn F. and William L. McKnight Brain Institute, University of Florida
Kaustuv Saha: Department of Neuroscience, Evelyn F. and William L. McKnight Brain Institute, University of Florida
Danielle Krout: Department of Basic Sciences, University of North Dakota School of Medicine and Health Sciences
Elizabeth Cabrera: Department of Neuroscience, Evelyn F. and William L. McKnight Brain Institute, University of Florida
Bruce Felts: Department of Basic Sciences, University of North Dakota School of Medicine and Health Sciences
L. Keith Henry: Department of Basic Sciences, University of North Dakota School of Medicine and Health Sciences
Jarod Swant: Department of Neuroscience, Evelyn F. and William L. McKnight Brain Institute, University of Florida
Mu-Fa Zou: Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse
Amy Hauck Newman: Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse
Habibeh Khoshbouei: Department of Neuroscience, Evelyn F. and William L. McKnight Brain Institute, University of Florida

DOI: https://doi.org/10.1038/ncomms10423
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The dopaminergic system has important roles in a number of cognitive process. Here, the authors use detailed analysis of dopamine transporter trafficking to show its levels at the cell surface are sensitive to changes in membrane potential.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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