JTO Clinical and Research Reports (Jan 2024)
Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report
- Emna Haddad, MD,
- Benjamin Bottet, MD,
- Pierre-Alain Thiebaut, MD, PhD,
- Samira Morin, MD,
- Hélène Dreyfus, MD,
- Élise Vannier, MD,
- Colette Vincent, MD,
- Florent Marguet, MD, PhD,
- Aude Lamy, PhD,
- Hagay Sobol, MD, PhD,
- Jean-Marc Baste, MD, PhD,
- Florian Guisier, MD, PhD,
- Jean-Christophe Sabourin, MD, PhD,
- Nicolas Piton, MD, PhD
Affiliations
- Emna Haddad, MD
- University of Rouen Normandy (UNIROUEN), Institut National de la Santé et de la Recherche Médicale (INSERM) U1245, Rouen, France; Department of Pathology, Hospital Center University De Rouen (CHU Rouen), Rouen, France
- Benjamin Bottet, MD
- Department of General and Thoracic Surgery, CHU Rouen, Rouen, France
- Pierre-Alain Thiebaut, MD, PhD
- University of Rouen Normandy (UNIROUEN), Institut National de la Santé et de la Recherche Médicale (INSERM) U1245, Rouen, France; Department of Pathology, Hospital Center University De Rouen (CHU Rouen), Rouen, France
- Samira Morin, MD
- Cabinet Medical, Infreville, France
- Hélène Dreyfus, MD
- Institut Sainte Catherine d’Avignon, Avignon, France
- Élise Vannier, MD
- Clinique Mathilde, Private Clinics, Rouen, France
- Colette Vincent, MD
- Centre Hospitalier Intercommunal (CHI) Elbeuf Louviers Val de Reuil, Saint-Aubin-lès-Elbeuf, France
- Florent Marguet, MD, PhD
- University of Rouen Normandy (UNIROUEN), Institut National de la Santé et de la Recherche Médicale (INSERM) U1245, Rouen, France; Department of Pathology, Hospital Center University De Rouen (CHU Rouen), Rouen, France
- Aude Lamy, PhD
- University of Rouen Normandy (UNIROUEN), Institut National de la Santé et de la Recherche Médicale (INSERM) U1245, Rouen, France; Department of Pathology, Hospital Center University De Rouen (CHU Rouen), Rouen, France
- Hagay Sobol, MD, PhD
- Département de Biologie du Cancer, Institut Paloi-Calmettes, Marseille, France; Faculté des Sciences Médicales et Paramédicales, Aix-Marseille University (AMU), Marseille, France
- Jean-Marc Baste, MD, PhD
- Department of General and Thoracic Surgery, CHU Rouen, Rouen, France
- Florian Guisier, MD, PhD
- Department of Pneumology, CHU Rouen, Rouen, France
- Jean-Christophe Sabourin, MD, PhD
- University of Rouen Normandy (UNIROUEN), Institut National de la Santé et de la Recherche Médicale (INSERM) U1245, Rouen, France; Department of Pathology, Hospital Center University De Rouen (CHU Rouen), Rouen, France
- Nicolas Piton, MD, PhD
- University of Rouen Normandy (UNIROUEN), Institut National de la Santé et de la Recherche Médicale (INSERM) U1245, Rouen, France; Department of Pathology, Hospital Center University De Rouen (CHU Rouen), Rouen, France; Corresponding author. Address for correspondence: Nicolas Piton, MD, PhD, Service d'Anatomie et Cytologie Pathologiques, Bâtiment Delarue, Centre Hospitalier Universitaire Charles Nicolle, 1 rue de Germont, 76031 Rouen, France.
- Journal volume & issue
-
Vol. 5,
no. 1
p. 100595
Abstract
Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly colorectal and uterine cancers. However, cancers with microsatellite instability outside this spectrum, for example, lung cancer, are extremely rare. Here, we report a case of squamous cell carcinoma of the lung with microsatellite instability in a patient with Lynch syndrome.
