Spontaneous intracranial hypotension complicated by a cerebral venous thrombosis following an mRNA COVID-19 vaccination: coincidence vs cause?

Abstract

Spontaneous intracranial hypotension (SIH) is a rare cause of persistent headache, particularly among young and middle-aged people. A potentially life-threatening complication of SIH is a cerebral venous thrombosis (CVT). The authors present a case in which a patient presented with SIH complicated by CVT one week after receiving a booster dose of mRNA COVID-19 vaccine. According to our literature review, this is the first such case report.

Keywords

• spontaneous intracranial hypotension
• cerebral venous thrombosis
• m-rna covid-19 vaccine
• headache