ANALYSIS OF THE ASSOCIATION OF POLYMORPHIC LOCUS RS1138272 OF GSTР1 GENE WITH BRONCHIAL ASTHMA AND PECULIARITIES OF ITS COURSE

Abstract

Aim. To study the association of polymorphic locus rs1138272 of GSTP1 gene with the risk of bronchial asthma and peculiarities of its course.Material and Methods.136 DNA samples of patients with bronchial asthma of varying severity and 147 healthy persons DNA sample were used for genotyping by polymerase chain reaction and restriction fragment length polymorphism.Results. We found the association of allele Val of polymorphic locus rs1138272 of GSTP1 gene with the severity of bronchial asthma and violation of external respiratory function, which is a prognostically unfavorable sign for the course of the disease. No significant skewing in the distribution of alleles and genotypes was seen between the patients and controls.Conclusion. In this study we revealed the association of polymorphic locus rs1138272 of GSTP1 gene with an increased risk of severe bronchial asthma.

Keywords

• bronchial asthma
• severity of disease
• genes
• polymorphism