Research Progress of Alternative Splicing in Oral Squamous Cell Carcinoma

Abstract

Alternative splicing is a key step in the regulation of post-transcriptional gene expression, and its dysfunction is closely related to tumorgenesis. This review systematically describes the regulation, specific events and development of prognostic model of alternative splicing in oral squamous cell carcinoma, to provide a new idea for the exploration of targeted therapy on oral squamous cell carcinoma.

Keywords

• oral squamous cell carcinoma
• alternative splicing
• heterogeneous nuclear ribonucleoprotein
• serine/arginine-rich proteins