Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs

Jeremy Dufourt; Antonio Trullo; Jennifer Hunter; Carola Fernandez; Jorge Lazaro; Matthieu Dejean; Lucas Morales; Saida Nait-Amer; Katharine N. Schulz; Melissa M. Harrison; Cyril Favard; Ovidiu Radulescu; Mounia Lagha

doi:10.1038/s41467-018-07613-z

Nature Communications (Dec 2018)

Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs

Jeremy Dufourt,
Antonio Trullo,
Jennifer Hunter,
Carola Fernandez,
Jorge Lazaro,
Matthieu Dejean,
Lucas Morales,
Saida Nait-Amer,
Katharine N. Schulz,
Melissa M. Harrison,
Cyril Favard,
Ovidiu Radulescu,
Mounia Lagha

Affiliations

Jeremy Dufourt: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535
Antonio Trullo: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535
Jennifer Hunter: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535
Carola Fernandez: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535
Jorge Lazaro: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535
Matthieu Dejean: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535
Lucas Morales: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535
Saida Nait-Amer: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535
Katharine N. Schulz: Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health Madison
Melissa M. Harrison: Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health Madison
Cyril Favard: Institut de Recherche en Infectiologie de Montpellier, CNRS, University of Montpellier UMR 9004
Ovidiu Radulescu: DIMNP, UMR CNRS 5235, University of Montpellier, Place E. Bataillon – Bât. 24 cc 107
Mounia Lagha: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS-UMR 5535

DOI: https://doi.org/10.1038/s41467-018-07613-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

Zelda is a pioneer factor that regulates transcription in Drosophila embryos. Here, the authors use quantitative live imaging and mathematical modeling to measure the effect of Zelda on transcriptional dynamics and memory, observing temporal control of gene expression by Zelda through transient interactions in hubs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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