Nature Communications (Mar 2018)
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state
- Vittoria Poli,
- Luca Fagnocchi,
- Alessandra Fasciani,
- Alessandro Cherubini,
- Stefania Mazzoleni,
- Sara Ferrillo,
- Annarita Miluzio,
- Gabriella Gaudioso,
- Valentina Vaira,
- Alice Turdo,
- Miriam Gaggianesi,
- Aurora Chinnici,
- Elisa Lipari,
- Silvio Bicciato,
- Silvano Bosari,
- Matilde Todaro,
- Alessio Zippo
Affiliations
- Vittoria Poli
- Laboratory of Chromatin Biology & Epigenetics, Center for Integrative Biology (CIBIO), University of Trento
- Luca Fagnocchi
- Laboratory of Chromatin Biology & Epigenetics, Center for Integrative Biology (CIBIO), University of Trento
- Alessandra Fasciani
- Laboratory of Chromatin Biology & Epigenetics, Center for Integrative Biology (CIBIO), University of Trento
- Alessandro Cherubini
- Fondazione Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”
- Stefania Mazzoleni
- Fondazione Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”
- Sara Ferrillo
- Fondazione Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”
- Annarita Miluzio
- Fondazione Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”
- Gabriella Gaudioso
- Fondazione Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”
- Valentina Vaira
- Fondazione Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”
- Alice Turdo
- Department of Surgical, Oncological and Stomatological Sciences, University of Palermo
- Miriam Gaggianesi
- Department of Surgical, Oncological and Stomatological Sciences, University of Palermo
- Aurora Chinnici
- Department of Surgical, Oncological and Stomatological Sciences, University of Palermo
- Elisa Lipari
- Department of Surgical, Oncological and Stomatological Sciences, University of Palermo
- Silvio Bicciato
- Center for Genome Research, University of Modena and Reggio Emilia
- Silvano Bosari
- Division of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
- Matilde Todaro
- DiBiMIS, University of Palermo
- Alessio Zippo
- Laboratory of Chromatin Biology & Epigenetics, Center for Integrative Biology (CIBIO), University of Trento
- DOI
- https://doi.org/10.1038/s41467-018-03264-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Breast cancer tumors originating from mammary luminal epithelial cells are highly heterogeneous. Here, the authors show MYC-driven tumor initiation is reliant on cell reprogramming via an epigenetic program which leads to mammary luminal epithelial cells acquiring basal/stem cell-like properties.
