Nature Communications (Nov 2017)
Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
- Mitsuteru Natsuizaka,
- Kelly A. Whelan,
- Shingo Kagawa,
- Koji Tanaka,
- Veronique Giroux,
- Prasanna M. Chandramouleeswaran,
- Apple Long,
- Varun Sahu,
- Douglas S. Darling,
- Jianwen Que,
- Yizeng Yang,
- Jonathan P. Katz,
- E. Paul Wileyto,
- Devraj Basu,
- Yoshiaki Kita,
- Shoji Natsugoe,
- Seiji Naganuma,
- Andres J. Klein-Szanto,
- J. Alan Diehl,
- Adam J. Bass,
- Kwok-Kin Wong,
- Anil K. Rustgi,
- Hiroshi Nakagawa
Affiliations
- Mitsuteru Natsuizaka
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- Kelly A. Whelan
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- Shingo Kagawa
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- Koji Tanaka
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- Veronique Giroux
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- Prasanna M. Chandramouleeswaran
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- Apple Long
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- Varun Sahu
- Abramson Cancer Center
- Douglas S. Darling
- Department of Oral Immunology and Infectious Diseases, and Center for Genetics and Molecular Medicine, University of Louisville
- Jianwen Que
- Department of Medicine, Division of Digestive and Liver Diseases, Columbia University
- Yizeng Yang
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- Jonathan P. Katz
- Gastroenterology Division, Department of Medicine, University of Pennsylvania
- E. Paul Wileyto
- Abramson Cancer Center
- Devraj Basu
- Abramson Cancer Center
- Yoshiaki Kita
- Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences
- Shoji Natsugoe
- Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences
- Seiji Naganuma
- Department of Pathology, Kochi Medical School
- Andres J. Klein-Szanto
- Histopathology Facility and Cancer Biology Program, Fox Chase Cancer Center
- J. Alan Diehl
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Adam J. Bass
- Dana–Farber Cancer Institute, Department of Medicine, Harvard Medical School
- Kwok-Kin Wong
- Dana–Farber Cancer Institute, Department of Medicine, Harvard Medical School
- Anil K. Rustgi
- University of Pennsylvania Perelman School of Medicine
- Hiroshi Nakagawa
- University of Pennsylvania Perelman School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-01500-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Notch receptors can exert different roles in cancer. In this manuscript, the authors reveal that Notch1 activation and EMT promote tumor initiation and cancer cell heterogeneity in squamous cell carcinoma, while the repression of Notch3 by ZEB1 limits Notch1-induced differentiation, permitting Notch1-mediated EMT.
