Factors of adherence to treatment with trospium in employees

Abstract

Aim: To conduct a comprehensive study of adverse factors and decreasing patients’ adherence during treatment with trospium. Materials and methods: During 12 months, 977 patients receiving trospium were studied regarding demographic, socioeconomic, and medical parameters by studying employer’s records, extracts from income tax returns, questionnaires OABq-SF, MOS SF-36, ICIQ-SF, and questionnaires concerning demographic and social status, voiding diaries, and uroflowmetry. Results: In total, 54.4% and 35.5% of patients preserved adherence to treatment with trospium during 6 months and 12 months, respectively. The average time of reaching a 30-day break in trospium administration was 182 days. Patients diagnosed with urge urinary incontinence and overactive bladder OAB (56.1%; 40.7%), having severe incontinence symptoms (56.1%), showing objectively high treatment efficacy (25.3%), and individuals subjectively satisfied with treatment outcome (57.5%) prevail among adherent patients, a significant minority is heavy coffee drinkers (14.5%). Individuals who are healthcare and education employees having annual and monthly income significantly higher than the mean income of patients receiving trospium also prevail among adherent patients (25.0%; 32.5%). Adherent patients are significantly older (56.3) than patients less adherent to the treatment. Conclusion: This experiment allowed for the first time the determination of the complexity of heterogeneous medical, socioeconomic, and demographic factors affecting patients’ adherence in treatment with trospium.

Keywords

• adherence of treatment
• employees
• incontinence
• lower urinary tract symptoms
• trospium