Effect of Guarem on the Body Weight and Basic Indices of Lipid and Carbohydrate Metabolism in Overweight or Obese Patients

Abstract

The article presents research findings of the Guarem effects on body weight, the basic indices of carbohydrate and lipid metabolism. Materials and Methods. We observed 40 patients divided into 3 groups. The first group (n = 12) — patients with newly diagnosed type 2 diabetes mellitus (DM), obesity or overweight and dyslipidemia; the second group (n = 14) — patients with overweight or obesity without DM and dyslipidemia; the third group (n = 14) — patients with type 2 DM and overweight or obesity, who receive insulin therapy. Results. On the background of Guarem administration with low-calorie diet and graded physical activity during 3 months, in the first group of patients we observed a decrease in body weight (2.57 ± 1.11 kg), atherogenic index (by 19 %), a significant reduction in postprandial glycemia (by 1.72 mmol/l, p < 0.001) and glycated hemoglobin (HbA1c) (by 0.89 %, p < 0.01); patients from the second group showed decrease in body weight (by 2.14 ± 0.16 kg) and WHR (by 3.47 %); the third group of patients reported a decrease in body weight (by 3.16 ± 0.16 kg) and a significant decrease in postprandial glycemia (by 1.45 mmol/l, p < 0.01) and HbA1c by (0.81 %, p < 0.05). All the patients noticed loss of appetite, early satiety, better tolerance of low-calorie diet. Such side effects as flatulence, bloating, bowel disorders, nausea were rare and quickly passed. Conclusions. Guarem has proven its efficacy in terms of effect on appetite, body weight, carbohydrate and fat metabolism parameters. The low percentage of side effects, as well as their transiency, shows a good safety profile and tolerability of Guarem.

Keywords

• obesity
• diabetes mellitus
• Guarem