DESTRUCTION OF POLYOXOMETALATE {Mo72Fe30} AS A TRANSPORT AGENT IN BLOOD SIMULATING MEDIA, ITS STABILIZATION BY ALBUMIN

Abstract

The creation and use of the targeted drug delivery systems based on nanocluster polyoxometalate {Mo72Fe30} implies its destruction in the body, accompanied by the gradual release of the drug. The rate constants of the destruction of pure {Mo72Fe30} and its associate with serum albumin in solutions simulating the blood media (phosphate buffer with pH 7,4 and blood serum of cattle) were determined. The stabilization of polyoxometalate by albumin in model solutions was shown. The ratio of components in the associate {Mo72Fe30}–albumin was determined, it was 1,6 polyoxometalate ions per albumin molecule.

Keywords

• polyoxometalate
• nanocluster
• {mo72fe30}
• protein corona
• targeted delivery
• the rate of destruction
• the rate constant of the reaction