Relationship of serum netrin-1 levels with breast masses

Abstract

Introduction: Netrin-1has been shown to induce angiogenesis and is considered to function as aproto-oncogene. We aimed to evaluate the relationship of serum netrin-1 levelwith the presence of breast mass and the nature of mass.Methods: A total of84 patients, including 27 patients with benign mass, 31 patients with malignantmass and 26 healthy controls, were enrolled in the study. Results: In ourstudy, the mean serum netrin-1 level was 479±325 pg/ml in the patients withmalignant mass, 336.9±178.2 pg/ml in the patients with benign mass and264.7±112.4 pg/ml in the healthy controls, respectively. There was astatistically significant difference in mean serum netrin-1 level between thesethree groups (p=0.007). When the patients participating in the study weredivided in to two groups as those with (the benign and malign groups) andwithout (the control group) mass, the mean serum netrin-1 level was 264.7±112.4pg/ml in those without mass and 412.8±274.2 pg/ml in those with mass,respectively. It was seen that the mean serum netrin-1 level of those with masswas statistically significantly higher than that of those without mass(p=0.016).Conclusion: The meanserum netrin-1 level was found to be significantly higher in the patients withbreast mass, especially those with malignant mass.

Keywords

• netrin-1
• meme kitleleri
• meme kanseri
• netrin-1
• breast masses
• breast cancer