Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity

Eva Janisiw; Marilina Raices; Fabiola Balmir; Luis F. Paulin; Antoine Baudrimont; Arndt von Haeseler; Judith L. Yanowitz; Verena Jantsch; Nicola Silva

doi:10.1038/s41467-020-18693-1

Nature Communications (Sep 2020)

Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity

Eva Janisiw,
Marilina Raices,
Fabiola Balmir,
Luis F. Paulin,
Antoine Baudrimont,
Arndt von Haeseler,
Judith L. Yanowitz,
Verena Jantsch,
Nicola Silva

Affiliations

Eva Janisiw: Department of Chromosome Biology, Max Perutz Laboratories, Vienna Biocenter, University of Vienna
Marilina Raices: Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine
Fabiola Balmir: Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine
Luis F. Paulin: Center for Integrative Bioinformatics Vienna (CIBIV), Max Perutz Laboratories, Medical University of Vienna, Vienna BioCenter, University of Vienna
Antoine Baudrimont: Department of Chromosome Biology, Max Perutz Laboratories, Vienna Biocenter, University of Vienna
Arndt von Haeseler: Center for Integrative Bioinformatics Vienna (CIBIV), Max Perutz Laboratories, Medical University of Vienna, Vienna BioCenter, University of Vienna
Judith L. Yanowitz: Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine
Verena Jantsch: Department of Chromosome Biology, Max Perutz Laboratories, Vienna Biocenter, University of Vienna
Nicola Silva: Department of Biology, Faculty of Medicine, Masaryk University

DOI: https://doi.org/10.1038/s41467-020-18693-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Poly(ADP-ribose) glycohydrolase (PARG) is involved in different cellular processes including DNA repair. Here the authors reveal a role for PARG in regulating meiotic DNA double strand break induction and repair in Caenorhabditis elegans.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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