Electroanalytical determination of metronidazole in tablet dosage form

Abstract

In this study, the electrochemical reduction and determination of metronidazole were easily realized in Britton-Robinson buffer (pH = 4.01) using UTGE by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. In this acidic medium, one irreversible and sharp cathodic peak was observed. A linear calibration curve for DPV analysis was constructed in the metronidazole concentration range 3x10-6 - 9x 10-5 mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were 1.42x10-7 and 4.76x10-7 mol L-1 respectively.

Keywords

• metronidazole
• determination
• voltammetry
• UTGE
• dosage form