Nature Communications (Sep 2018)

Identification of small-molecule ion channel modulators in C. elegans channelopathy models

  • Qiang Jiang,
  • Kai Li,
  • Wen-Jing Lu,
  • Shuang Li,
  • Xin Chen,
  • Xi-Juan Liu,
  • Jie Yuan,
  • Qiurong Ding,
  • Feng Lan,
  • Shi-Qing Cai

DOI
https://doi.org/10.1038/s41467-018-06514-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Mutations in the voltage-gated K+ channel human ether-a-go-go-related gene (hERG) lead to Long-QT syndrome, causing life-threatening cardiac arrhythmia. Here the authors use C. elegans as a platform to run a channelopathy drug screen, identifying drugs to target hERG mutants.