Towards Recyclable NAD(P)H Regeneration Catalysts

Abstract

Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp<strong>*</strong>Rh(bpy)(H₂O)]²⁺ was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.

Keywords

• biocatalysis
• cofactor regeneration
• chemoenzymatic cascades
• immobilized catalysts