A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

Yosi Gilad; Yossi Eliaz; Yang Yu; Adam M. Dean; San Jung Han; Li Qin; Bert W. O’Malley; David M. Lonard

doi:10.1038/s42003-021-01929-1

Communications Biology (Mar 2021)

A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells

Yosi Gilad,
Yossi Eliaz,
Yang Yu,
Adam M. Dean,
San Jung Han,
Li Qin,
Bert W. O’Malley,
David M. Lonard

Affiliations

Yosi Gilad: Department of Molecular and Cellular Biology, Baylor College of Medicine
Yossi Eliaz: Department of Molecular and Human Genetics, Baylor College of Medicine
Yang Yu: Department of Molecular and Cellular Biology, Baylor College of Medicine
Adam M. Dean: Department of Molecular and Cellular Biology, Baylor College of Medicine
San Jung Han: Department of Molecular and Cellular Biology, Baylor College of Medicine
Li Qin: Department of Molecular and Cellular Biology, Baylor College of Medicine
Bert W. O’Malley: Department of Molecular and Cellular Biology, Baylor College of Medicine
David M. Lonard: Department of Molecular and Cellular Biology, Baylor College of Medicine

DOI: https://doi.org/10.1038/s42003-021-01929-1
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 17

Abstract

Read online

Using a CRISPR-based large-scale screen, Gilad et al. identify the genes that show synthetic lethality with an SRC-3 inhibitor in breast cancer cells while contrasting this with the estrogen receptor degrader fulvestrant. This study provides insights into the development of therapeutic strategies for cancer forms that involve SRC-3.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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