Nature Communications (Sep 2021)

A comprehensive map of alternative polyadenylation in African American and European American lung cancer patients

  • Adriana Zingone,
  • Sanju Sinha,
  • Michael Ante,
  • Cu Nguyen,
  • Dalia Daujotyte,
  • Elise D. Bowman,
  • Neelam Sinha,
  • Khadijah A. Mitchell,
  • Qingrong Chen,
  • Chunhua Yan,
  • Phillipe Loher,
  • Daoud Meerzaman,
  • Eytan Ruppin,
  • Bríd M. Ryan

DOI
https://doi.org/10.1038/s41467-021-25763-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Alternative polyadenylation (APA) regulates the length of the 3′UTR of mRNA. Here, the authors describe a method to accurately measure APA in tumours and apply this method to investigate the differences in APA in African American and European American lung cancer samples.