Frontiers in Immunology (Feb 2022)

Role of Histone Post-Translational Modifications in Inflammatory Diseases

  • Yingying Lin,
  • Yingying Lin,
  • Ting Qiu,
  • Ting Qiu,
  • Guifeng Wei,
  • Guifeng Wei,
  • Yueyue Que,
  • Yueyue Que,
  • Wenxin Wang,
  • Wenxin Wang,
  • Yichao Kong,
  • Yichao Kong,
  • Tian Xie,
  • Tian Xie,
  • Xiabin Chen,
  • Xiabin Chen

DOI
https://doi.org/10.3389/fimmu.2022.852272
Journal volume & issue
Vol. 13

Abstract

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Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer’s disease, psoriasis, asthma, chronic lung diseases, inflammatory bowel disease, and multiple virus-associated diseases. Epigenetic mechanisms have been demonstrated to play a key role in the regulation of inflammation. Common epigenetic regulations are DNA methylation, histone modifications, and non-coding RNA expression; among these, histone modifications embrace various post-modifications including acetylation, methylation, phosphorylation, ubiquitination, and ADP ribosylation. This review focuses on the significant role of histone modifications in the progression of inflammatory diseases, providing the potential target for clinical therapy of inflammation-associated diseases.

Keywords