Journal of Nature and Science of Medicine (Jan 2019)

Possible immunochemical pattern of anti-HCV, HBeAg, HBsAg HBeAb, and HIV-1 p24 in newly infected Mycobacterium pulmonary tuberculosis patients

  • Mathew Folaranmi Olaniyan,
  • Ruth Aderibigbe,
  • Temitayo Afolabi

DOI
https://doi.org/10.4103/JNSM.JNSM_66_18
Journal volume & issue
Vol. 2, no. 3
pp. 130 – 134

Abstract

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Background: Viral biomarkers in pulmonary tuberculosis (PTB) could be a primary or secondary viral infection to PTB which may depressed immunity or make the patient susceptible to the secondary infection. Aim and Objective: This work was, therefore, designed to determine frequency of anti-hepatitis C virus (HCV), hepatitis B envelope antigen (HBeAg), hepatitis B surface antigen (HBsAg), hepatitis B envelope antibody (HBeAb), and human immunodeficiency virus (HIV)-1 p24 in newly infected Mycobacterium PTB patients. Materials and Methods: Sixty newly infected Mycobacterium tuberculosis patients were recruited from the medical outpatient Department of Baptist Medical center, Saki-Nigeria. The patients were classified into females (30) and males (30) aged 38–79 years. M. tuberculosis was determined in the patients through fluorescence immunoassay, cultivation of sputum sample on Löwentein–Jensen medium, and radiological chest X-ray report. Anti-HCV, HBeAg, HBsAg HBeAb, and HIV-1 p24 were determined in the patients by immunochromatography and ELISA methods. Results: The viral immunochemical pattern obtained in the newly infected PTB patients showed a frequency of: 5% (3) (males - 3.3% [2] and females - 1.67% [1]) anti-HCV; 3.3% (2) (all males - 3.3% [2]) HIV-1 - p24; 15% (9) (males - 3 [5%] and females - 6 [10%]) HBsAg; 9 (15%) (males - 5% [3] and females - 10% [6]) HBeAg; 18.33% (11) (males - 6.7% [4] and females - 11.67% [7]) hepatitis B envelope (HBe) antibody; 3.33% (2) (males - 1.67%[1] and females - 1.67% [1]) HBeAg + HBsAg + HIV-1 - p24. Conclusion: This work revealed evidence of anti-HCV; HIV-1 - p24; HBsAg; HBeAg; and HBe antibody and HBeAg + HBsAg + HIV-1 - p24 in newly infected pulmonary M. tuberculosis-infected patients. Routine evaluation of viral biomarkers in PTB patients is necessary for effective management.

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