TGF-β1 and HSP-47 expression in pterygium

Abstract

AIM:To investigate the expression transforming growth factor-β1(TGF-β1)and heat shock protein 47(HSP-47), in pterygium and normal conjunctiva tissues, in order to study the roles of these cytokines played in the pathogenesis in human pterygium. METHODS:The expression difference of TGF-β1, HSP-47 between human pterygium and normal conjunctive tissues were compared by immuno-histochemistry technique. RESULTS:The positive expression of TGF-β1, HSP-47 was stronger than in normal conjunctive tissues(PCONCLUSION:Over-expression of TGF-β1 and HSP-47 in pterygium compared to the normal conjunctiva tissues may play a critical role during the occurrence, development and invasion of the pterygium.

Keywords

• pterygium
• TGF-β1
• HSP-47
• HSP-47