Early Postischemic Cerebral Circulatory Disorders and Their Correction with Perftoran

Abstract

Objective: to study the conditions and mechanism of postischemic no-reflow and delayed hypoperfusion and to correct them with perfluorane.Materials and methods: Both phenomena were reproduced by using a rat model of global cerebral ischemia.Results: no-reflow was shown to be caused by pial arteriolar collapse that occurred in ischemia and lasted during reperfusion. Delayed postischemic hypoperfusion was induced by increased pial arteriolar tone.Conclusion: Intraarterial injection of perfluorane alleviates the manifestation of both phenomena due to better oxygen supply to ischemic brain tissue and, probably, to calcium channel blockage.

Keywords

• cerebral ischemia
• no-reflow
• delayed hypoperfusion
• perfluorane