Frontiers in Bioengineering and Biotechnology (Jul 2023)

Biosafety evaluation of BaSi2O2N2:Eu2+/PDMS composite elastomers

  • Zheyuan Zhang,
  • Zheyuan Zhang,
  • Mingrui Zong,
  • Mingrui Zong,
  • Jinrong Liu,
  • Jinrong Liu,
  • Jianing Ren,
  • Jianing Ren,
  • Xiaoming Liu,
  • Xiaoming Liu,
  • Ran Zhang,
  • Ran Zhang,
  • Jiayu Cui,
  • Jiayu Cui,
  • Lingxiang Sun,
  • Lingxiang Sun,
  • Hao Song,
  • Yanjie Zhang,
  • Bing Li,
  • Bing Li,
  • Xiuping Wu,
  • Xiuping Wu

DOI
https://doi.org/10.3389/fbioe.2023.1226065
Journal volume & issue
Vol. 11

Abstract

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In recent years, mechanoluminescent (ML) materials have shown great potential in stress sensing, mechanical energy collection and conversion, so they have attracted wide attention in the field of stomatology. In the early stage of this study, BaSi2O2N2:Eu2+ ML phosphors were synthesized by two-step high temperature solid state method, and then mixed with Polydimethylsiloxane (PDMS) in different proportions to obtain BaSi2O2N2:Eu2+/PDMS ML composites with different mass fractions (10%,20%,30%,40%,50%). Then its biosafety was evaluated by Cell Counting Kit-8 (CCK-8), Calcein-AM/PI fluorescence staining, hemolysis, oral mucosal irritation, acute and subacute systemic toxicity tests. The experimental results show that the biosafety of BaSi2O2N2:Eu2+/PDMS ML composite elastomers with different mass fraction is in line with the existing standards, and other related properties can be further studied.

Keywords