SDF-1 and its receptor in the ventricles of rat with monocrotaline-induced pulmonary hypertension

Abstract

Aim: Chemokine stromal cell derived factor-1 (SDF-1) plays an important role in many processes such as apoptosis, proliferation, migration and angiogenesis, and these effects are mediated mostly by the receptor CXCR4. The aim of this study was to determine the expression of SDF-1 and CXCR4 in the ventricles of rats with monocrotaline-induced pulmonary hypertension.

Keywords

• pulmonary hypertension
• monocrotaline
• stromal cell-derived factor 1
• ventricles