Nature Communications (Nov 2018)

NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells

  • Susan L. Kloet,
  • Ino D. Karemaker,
  • Lisa van Voorthuijsen,
  • Rik G. H. Lindeboom,
  • Marijke P. Baltissen,
  • Raghu R. Edupuganti,
  • Deepani W. Poramba-Liyanage,
  • Pascal W. T. C. Jansen,
  • Michiel Vermeulen

DOI
https://doi.org/10.1038/s41467-018-07063-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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The NuRD complex plays an important role in regulating lineage commitment and cell fate during early embryonic development. Here the authors present an integrative analysis of MBD3/NuRD composition and binding in mouse embryonic stem cells and neural progenitor cells, providing a molecular basis for genome-wide NuRD localization