Romanian Journal of Military Medicine (Dec 2016)

Modern medicine has a new technology: therapeutic electroporation

  • Lucia E. Ionescu,
  • Diana M. Popescu,
  • Gabriela V. Dumitrescu,
  • Simona N. Bicheru,
  • Marius Necșulescu,
  • Viorel Ordeanu

Journal volume & issue
Vol. CXIX, no. 3
pp. 29 – 34

Abstract

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Electroporation is considered a new start-up in the treatment of various tumors; currently, researches are being conducted in order to develop this technology with medical applications. The technique consists in the significant increase in the electrical conductivity and permeability of the plasma membrane of cells resulting from the application of an external electric field. It is routinely used in molecular biology to transform bacteria, yeast, protoplasts and is performed using the electroporators. Currently, the process seems to be a real solution that enables a targeted drug to act with maximum efficiency on cells and tissues requiring treatment, resulting in obtaining a good therapeutic effect without major side effects. Therefore, pharmaceutical companies are trying to demonstrate through preclinical studies the potential efficacy of this technology, succeeding in recent years to achieve important steps in this direction.

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